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According to new research, psoriasis patients are treated with biological therapy, which is a protein-based infusion to reduce inflammation. This helps to remove plaque in the arteries of the heart for over a year. According to a study published in the American Heart Association Journal on Cardiovascular Imaging on 15 September, people with psoriasis have an increased risk of inflammation in the coronary artery. Biologic therapy medications are proteins given by injection or infusion and reduce inflammation by blocking the action of cytokines. Also read: Those with heart disease should note: These bacteria can be a boon for you.
Previous research has shown high risk of plaque in psoriasis and coronary, a clear link between the two. This study gives a characterization of a lipid-rich necrotic core, a dangerous type of coronary plaque made up of dead cells and cell debris, which is at risk of bursting, causing its rupture. May cause heart attack or stroke.
Dr. Nehal N Mehta, MD, MSCE, FAHA, a senior author, stated in his study that, “inflamed plaques that are prone to eruption increase the risk of heart attack five-fold within ten years.” For the first time, a year-long imaging study in humans has shown that untreated inflammation can reverse the damage to the heart’s arteries. Untreated inflammation is very dangerous. It can cause heart attacks and strokes, Doctor Mehta said this.
The analysis included 209 middle-aged patients (aged 37–62 years) with psoriasis who participated in the Psoriasis Atherosclerosis Cardiometabolic at the National Institutes of Health, 124 of these participants after continued observation in the study. Received biologic therapy and 85 were in the control group, treated only with topical creams and light therapy. Also read: If you want to avoid heart disease then do at least this many push-ups daily
To measure the effects of biologic therapy on the arteries of the heart, the researchers performed cardiac computed tomography (CT) scans on all study participants before starting therapy and one year later. The CT results were then compared between the two groups.
At the beginning of the study, psoriasis participants had lower cardiovascular risk than traditional cardiovascular risk scores, and severe psoriasis had higher body mass index (BMI), higher sensitivity C-reactive protein ( high-sensitivity C-reactive protein) and was associated with high levels of coronary artery plaques.
After one year of treatment, patients who received biologic therapy were compared to the control group. Researchers found that biotherapy was associated with an 8 percent decrease in coronary plaque. In contrast, people in the control group slightly increased the progression of the coronary plaque. Coronary plaque was reduced in patients treated with biologic therapy even after adjusting for cardiovascular risk factors and severity of psoriasis.
Coronary plaque decreases by approximately 6–8% after treatment with statins. Similarly, after one year, our treatment with biological treatment by the same amount reduced the coronary plaque. These findings suggest that biological therapy for the treatment of psoriasis can be just as beneficial as statin therapy on the arteries of the heart, ”said Dr. Mehta.
This study also increases the risk of heart disease for people with psoriasis and possibly for people with other chronic inflammatory conditions such as HIV, lupus and rheumatoid arthritis.
Mehta stated, “We have never before been able to show the treatment of such inflammatory plaques in humans. Biologic therapy reduces systemic inflammation and immune activation and It has a favorable effect on the improvement of vascular health, “imagine if we can treat both psoriasis and coronary heart disease simultaneously – this is a question to be asked in future studies.”
The findings of the study should be interpreted cautiously as it was limited by a shorter follow-up period and lower number of patients. Randomcontrol studies are needed to better understand that changes in coronary plaque may reduce heart attacks and stroke in people with psoriasis.